Comparison of genome-wide DNA methylation between H446/DDP and H446. Comparison of genome-wide DNA methylation between H446/DDP and H446

Little has been known about the genome-wide methylation frameworks of the chemo-resistant cells of SCLC currently, which might provide prospective layouts to discover the genes and the signal pathways related with chemo-resistance of SCLC. Thus, this research reported for the first time the genome-wide abnormal methylation pattern of chemo-resistant H446/DDP cells of human SCLC induced by the cisplatin Overall design: Illumina Infinium Human Methylation 450K bead chip