Induced expression of ectopic myelin genes by the transcription factor SOX10 in an enteric glial cell line

This study investigates the impact of Sox10 overexpression on enteric glial cell (EGC) phenotype using a doxycycline-inducible EGC cell line. Sox10 overexpression upregulated genes were associated with myelin regulation and glial differentiation pathways, resembling Schwann cell or oligodendrocyte-specific SOX10 target genes. These findings suggest cell-specific regulation of glial phenotype by SOX10 dosage and identify potential target genes, contributing to our understanding of EGC diversity. Rat enteric glial cell line (JUG2) were generated to overexpress SOX10 or GFP after treatment with doxycycline. Genome-wide expression analysis was performed using Clariom S microarray