Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

ChEBI2015-08-26 更新2026-07-12 收录

抗体类别转换重组

DNA断裂修复机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-71005 数据链接链接失效反馈

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Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

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2015-08-26

Ubiquitin-dependent transfer of PAF1c from MYC onto RNA Polymerase controls double-strand break repair at active promoters [ChIP-seq BI8626]

转录调控

DNA断裂修复机制

MYC family proteins are oncogenic transcription factors that can globally affect the function of RNA Polymerase II (RNAPII). The ability of MYC proteins to promote transcription elongation depends on

干细胞与再生医学数据中心2022-02-20 更新110

Arabidopsis thaliana Uracil-DNA-Glycosylase mitochondrial mutation accumulation study

线粒体DNA修复

DNA断裂修复机制

Substitution rates in plant mitochondrial genes are extremely low, indicating strong selective pressure as well as efficient repair. Plant mitochondria possess base excision repair pathways, however,

NIAID Data Ecosystem60

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro. Mus musculus

抗体类别转换重组

杂交瘤技术

This is a comparative microarray analysis of 36-65 hybridomas switching at normal low frequencies in vitro vs. selected variants spontaneously switching at 100 fold higher frequencies in vitro. This a

NIAID Data Ecosystem40

Slx4 and Rtt107 control checkpoint signaling and DNA resection at double-strand breaks. Saccharomyces cerevisiae

DNA损伤应答

DNA断裂修复机制

The DNA damage checkpoint pathway is activated in response to DNA lesions and replication stress to preserve genome integrity. However, hyper-activation of this surveillance system is detrimental to t

NIAID Data Ecosystem70

Genes involved in DNA double strand break signaling and repair in Arabidopsis.

DNA修复

DNA断裂修复机制

Listed according to Amiard et al. (2013) [49]. Additional genes involved in DNA repair identified using AgriGo (Go Analysis Toolkit and Database for Agricultural Community) [26] are added. Arabidopsis

NIAID Data Ecosystem50

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

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