SNPs with genome-wide significant evidence for association with central adiposity and fat distribution.

Alleles: the first allele listed in the parenthesis is the effect allele, for which the allele frequency is given.
Stage 1: data from stage 1 GIANT GWAS meta-analysis.
Stage 2a: data from meta-analysis of in silico studies.
Stage 2b: data from meta-analysis of de novo genotyped studies.
Stage 1+2: data from stage 1 GIANT analyzed with in silico studies (Stage 2a) and de novo genotyped studies (Stage 2b).
Overall: data from meta-analysis of Stage1, 2a, 2b and CHARGE.
*Total sample sizes do not always reflect the sum of component studies due to (a) rounding errors in non-integeric sample sizes arising from the weighting procedure; (b) overlap, for some markers, of data from the Rotterdam and ERF cohorts (up to 6,702 individuals) which were included in both CHARGE and stage 2 data, but which are counted only once in the overall analysis.
**P-values: all P-values we report here are two-sided.
†For the MRSA locus, genotypes for rs7826222 were only available for a subset of the CHARGE samples (N = 8,097). This is likely due to the fact that this SNP has been renamed to rs545854 in NCBI build 36 and was consequently one of the SNPs omitted from HapMap release 22 and therefore is not present in build 36 imputations based on that release of HapMap.
- Data not available. Effect size estimates and overall WHR results are not available as CHARGE only analysed WC using the weighted Z-score method (see Methods).