The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis

ChEBI2014-03-27 更新2026-07-21 收录

免疫衰老

细胞因子调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-49968 数据链接链接失效反馈

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The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis

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2014-03-27

Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines

感染免疫机制

细胞因子调控

Caspase-6 is a member of the executioner caspases and known to play a role in innate and adaptive immune processes. However, its role in infectious diseases has rarely been addressed yet. We here exam

NIAID Data Ecosystem90

Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans. Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans

免疫衰老

CD8+T细胞衰老

Aging leads to a progressive functional decline of the immune system, rendering the elderly increasingly susceptible to disease and infection. The degree to which immune cell senescence contributes to

NIAID Data Ecosystem60

Interleukin-6 Deficiency Influences Cytokine Expression in Susceptible BALB Mice Infected with Leishmania major but Does Not Alter the Outcome of Disease

感染免疫学

细胞因子调控

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(−/−)) mice with Leishmania major. There was not a significant difference between the courses of infection (l

PubMed Central50

GO:0032736 (positive regulation of interleukin-13 production)

细胞因子调控

生物通路挖掘

This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.

NIAID Data Ecosystem60

RNA-seq comparison of gene induction in RIG-I stimulated old and young human monocytes

免疫衰老

单细胞转录组学

Goal: The goal of this study was to compare gene induction in old and young human monocytes upon stimulation of these cells with a RIG-I specific ligand, based on previously published results which in

NIAID Data Ecosystem60

The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis

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