GPR126 SNP rs536714306 association analysis with periodontitis in Greek population. A GPR126 single nucleotide polymorphism (rs536714306) is not associated with periodontitis: A study in a Greek cohort

BACKGROUND: G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the association of the GPR126 [c.3086 G>A] (rs536714306) polymorphism with periodontitis in a Greek population. METHODS: A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. RESULTS: No polymorphic variants in the GPR126 gene were detected in any of the samples. The wild-type GG genotype was observed in 100% of participants across both groups (P and H). CONCLUSIONS: No association was found between the GPR126 [c.3086 G>A] polymorphism and susceptibility to periodontitis in a Greek cohort. This is the first report evaluating this polymorphism in periodontitis patients in a European population. While limited by sample size, these findings contribute to the growing body of knowledge on genetic factors in periodontitis. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.