Longitudinal ovarian cancer (BOB). Longitudinal ovarian cancer (BOB)

High-grade serous ovarian cancer presents significant challenges due to its poor prognosis and high heterogeneity, both of which complicate treatment responses. This project aims to understand intra-patient tumor evolution by investigating different sampling sites (primary and metastatic) at the time of diagnosis and during disease recurrence. A total of 183 biopsies from 50 patients were collected for this purpose, and bulk mRNA sequencing was performed. The majority of samples originated from following tissue types: omentum, ovary, and ascites. Overall design: The samples included in this cohort are derived from clinical biopsies of patients diagnosed with high-grade serous ovarian cancer. *************************************************************** Raw sequencing data from human patient samples were not submitted to GEO due to data-protection considerations. Controlled access to the raw files is provided through the European Genome-phenome Archive (EGA; accession EGAD50000002064) via the MF-DAC. ***************************************************************