Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles Supplementary Dataset

AIDS causes increasing mortality every year.With advancements in nanomedicine, different nanomaterials
(NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles
(NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities
and facilitation of drug dose reductions. This review discusses recent advancements in therapeutics for
AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic
NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use
of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent
advances, current challenges and future perspectives on the use of these NMs for better management of
HIV/AIDS are also discussed.

艾滋病每年导致死亡率不断攀升。随着纳米医学的进步，多种纳米材料（NMs）已被应用于治疗艾滋病并克服其局限性。在这些纳米材料中，纳米颗粒（NPs）由于其增强的溶解性、持续的释放、靶向能力以及降低药物剂量的便利性，可以作为纳米载体。本综述讨论了使用各种纳米材料（NMs）治疗艾滋病/HIV的最新进展，主要聚焦于三大类：聚合物纳米材料、脂质体纳米材料和无机纳米材料。包括聚合物树状大分子、聚乙烯亚胺-NPs、聚（乳酸-羟基乙酸共聚物）-NPs、壳聚糖以及基于脂质体的递送系统和包括金纳米颗粒和银纳米颗粒在内的无机纳米材料的使用都得到了探讨。同时，还讨论了这些纳米材料用于更有效地管理HIV/AIDS的最新进展、当前挑战及未来展望。