Variability of metabolomic profiles in terms of variables related to clinical and laboratory parameters in the four principal components identified and expressed as F-values together with the corresponding p-values (in brackets).

ANOVA test, significant values (p<0.05) are in bold.
The results showed a correlation between PC3 scores and CRP levels and between PC1 scores and tender joint count. This last parameter only could affect the response to etanercept: in fact, the median tender joint count 28 (range) was 8 (0–21) and 12 (6–25) for responder and non-responder groups, respectively.
ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; VAS: visual analogue scale; HAQ: Health Assessment Questionnaire; DAS28: disease activity score based on 28 joint counts.
Variability of metabolomic profiles in terms of variables related to clinical and laboratory parameters in the four principal components identified and expressed as F-values together with the corresponding p-values (in brackets).