Single-cell RNA sequencing reveals the evolution of immune landscape during perihematomal edema progression after intracerebral hemorrhage

The complicated immune response in the post-intracerebral hemorrhage brain constitutes a crucial component of perihematomal edema pathophysiology. Here, we aimed to characterize the transcriptional profiles of immune cell populations in human PHE tissue Overall design: A multi-stage profile was developed, comprising Group1 (n=3, 0-6 hours post-ICH, G1), Group2 (n=3, 6-24 hours post-ICH, G2), and Group3 (n=3, 24-48 hours post-ICH, G3).We employed single-cell RNA sequencing scRNA-seq to comprehensively map the immune cell populations in post-intracerebral hemorrhage samples which were resected from patients at different stages of post-ICH