Crystal structure of human Sirt2 in complex with a pyrazole-based fragment inhibitor and NAD+

Crystal structure of human Sirt2 in complex with a pyrazole-based fragment inhibitor and NAD+ Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Friedrich, F, Einsle, O, Jung, M. Deposit date: 2024-06-19 Release date: 2025-06-04 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions. J.Med.Chem., 68, 2025