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Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues

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Figshare2016-02-12 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Total_Syntheses_and_Biological_Evaluation_of_Botryosphaeridione_Pleodendione_4_i_epi_i_Periconianone_B_and_Analogues/2109568
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The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.
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2016-02-12
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