Clinical and MRI data.

Expressed are mean values and standard deviation, except for EDSS and FS cerebellar scores, where a median and range are provided.9HPT: nine-hole peg test; EDSS: Expanded Disability Status Scale; FS: functional system; GA: glatiramer acetate; GM: grey-matter; IFN: interferon; IM: intramuscular; NA: not applicable; PASAT: Paced Auditory Serial Addition Test; RRMS: relapsing-remitting multiple sclerosis; SC: subcutaneous; SDMT: Symbol Digit Modalities Test; T25FW: timed twenty-five foot walk test; WM: white-matter.* Group comparisons were performed with Mann-Whitney U tests for age and education; Fisher's exact test for gender distribution; and the General Linear Model with gender and total intracranial volume as covariates for volumes comparisons and with education as covariate for clinical tests performances.