Concentration of selected proteins in plasma of patient with soft tissue infections or sepsis

The dataset includes two tabular sets of concentration measurements of
selected proteins in plasma samples from patients with soft tissue
infections or sepsis. Patients with soft tissue infections are classified
into three groups: Patients with necrotizing soft tissue infections
(NSTI), suspected NSTI cases but where no necrotic tissue was found during
surgical exploration (Non-NSTI) and cellulitis. The sepsis patient cohort
has heterogeneous etiologies and location of infection. Additionally, we
included a group of patients that had surgery related to non-infectious
conditions as a healthy cohort of patients (Surgical control). The
measurements were performed by Luminex® multiplex immunoassay or ELISA.
Each of the two sets were obtained from independent rounds of measurements
and differ in the panel of analytes measured and samples included. The
first set of measurements (Set01) covers 39 analytes measured in two sets
of customized multiplex plates (32-plex and 5-plex), and two in
independent ELISA assays. These analytes were measured in 251 NSTI
samples, 20 Non-NSTI, 19 cellulitis and 20 surgical controls. The second
set of measurements (Set02) consist of a subset of 10 analytes included in
the first set and were measured in two multiplex plates (4-plex and
6-plex). The second round of measurements were carried out in 60
additional NSTI patients and 24 sepsis patients. Lastly, imputation of
censored data was carried out only in the first set of measurements and
the resulting data is also available in the current data set
(Set01_imputed).