Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE155572
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Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expression level Methods: NB4 cells treated with DMSO or Tan I 10 μM were collected for RNA sequencing Results: We found that 376 genes were differentially expressed between DMSO and Tan I treatment in the NB4 cells (p value <=0.05, |log2 fold change| >= 0.25) Conclusions: We identified MMP9 and ABCG2 as two possible downstream genes of Tan I’s effects on EZH2 NB4 cells treated with DMSO or Tan I 10 μM
创建时间:
2021-06-09



