Palladium-Catalyzed C(sp3)–H Biarylation of 8‑Methyl Quinolines with Cyclic Diaryliodonium Salts to Access Functionalized Biaryls and Fluorene Derivatives

Herein, we have developed the cyclic diaryliodonium salts as biarylating agents in the C(sp3)–H functionalization using 8-methyl quinoline as the intrinsic directing group. The oxidant-free reaction produces a vast array of the biarylated products with iodo functionality that can be further functionalized. Additionally, intramolecular C(sp3)–H functionalization in a stepwise manner under palladium-catalyzed conditions produced the fluorene derivatives in excellent yields.