Additional file 3: Figure S2. of Molecular evolution of HIV-1 integrase during the 20Â years prior to the first approval of integrase inhibitors

Relation between significant coupling and frequency of single/pairwise substitutions. a) Relation between the relative frequencies of substitution pairs within the MSA and the strength of their coupling values (only significant couplings are considered). b) Relation between the relative frequencies of single substitutions within the MSA and their absolute frequency in significant couplings. (ZIP 133Â kb)