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Direct C‑2 Arylation of 7‑Azaindoles: Chemoselective Access to Multiarylated Derivatives

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https://figshare.com/articles/dataset/Direct_C_2_Arylation_of_7_Azaindoles_Chemoselective_Access_to_Multiarylated_Derivatives/2352919
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Pd-catalyzed direct C–H arylation of N-methyl-7-azaindole at the C-2 position by diverse arylboronic acids was achieved at room temperature. The method is general and was applied in chemoselective synthesis of multiarylated 7-azaindole derivatives bearing three different aryl groups at the 2, 3, and 5 positions.
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2016-02-18
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