Analysis of transcriptome in mouse tissue following Mycobacterium avium subsp. paratuberculosis infection

Purpose : Comparative analysis of host transcriptomes according to infection route following MAP infection Methods : Mice were infected with MAP by oral/intraperitoneal (IP) route. Total RNA were harvested from spleen and mesenteric lymph node after 6 weeks. RNA-seq was performed with total RNA of each sample. Results : Canonical pathway analysis showed that LXR/RXR activation pathway had negative z-score in IP group, whereas positive in oral group. Overall design: Gene expression analysis with animal model using RNA-seq analysis