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Asymmetric Iodolactamization Induced by Chiral Oxazolidine Auxiliary

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Asymmetric_Iodolactamization_Induced_by_Chiral_Oxazolidine_Auxiliary/3316090
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Asymmetric iodolactamization reactions of unsaturated amides with oxazolidines as the chiral auxiliaries were investigated. With (4S)-4-((2R)-2-butyl)-2,2-dimethyloxazolidine as the auxiliary and LiH as the base, a number of unsaturated amides underwent iodolactamization smoothly to afford the corresponding γ- and δ-lactams in 30−98% yield with de values up to 97%.
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2016-05-06
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