Effect of tissue co-engraftment on tumor development.

Comparison of the relative tumor size of ectopic/orthotopic implantation of tumor spheroids in FVB versus nude mice. N202 tumor spheroids expressing H2B-GFP were implanted in FVB or nude mice with the donor mammary fat pad tissue, allowed to revascularize, and imaged by IVM to measure tumor size by total fluorescence signal on the indicated day post tumor implantation. Again, the growth of the tumors are observed to be very similar.

本研究对比了在FVB与裸鼠中，异位/同位移植肿瘤球体的相对肿瘤大小。N202肿瘤球体表达H2B-GFP蛋白，并被植入FVB或裸鼠的供体乳腺脂肪垫组织中，待其重新血管化后，通过光学生物显微镜（IVM）在指定的肿瘤移植后第几天进行成像，以总荧光信号测量肿瘤大小。再次观察，肿瘤的生长表现极为相似。