BCRseq of sorted human peripheral blood naive B cells
收藏NIAID Data Ecosystem2026-03-13 收录
官方服务：
资源简介：
Analysis of somatic hypermutation and clonal expansion in human peripheral blood naive B cells isolated with different sorting strategies.
应用场景：
创建时间：
2022-08-05
相关数据集
HIRA-dependent H3.3 deposition and its modification H3.3K36me3 facilitate somatic hypermutation of immunoglobulin genes by maintaining the proper chromatin state and transcription
The H3.3 histone variant and its chaperone HIRA are involved in active transcription but their detailed roles in regulating somatic hypermutation (SHM) of immunoglobulin variable regions in human B ce
NIAID Data Ecosystem70
UNG shapes the specifity of AID-induced somatic hypermutation in non B cells
Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) init
NIAID Data Ecosystem60
Raw data of next-generation sequencing (NGS) in [RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase. Yin & Kobayashi et al]
To investigate the effect of RNA-binding motifs of heterogeneous nuclear ribonucleoprotein K on activation-induced cytidine deaminase-dependent somatic hypermutation, NGS was performed using a pooled
NIAID Data Ecosystem50
Language model-based B cell receptor sequence embeddings can effectively encode receptor specificity
High throughput sequencing of B cell receptors (BCRs) is increasingly applied to study the immense diversity of antibodies. Learning biologically meaningful embeddings of BCR sequences is beneficial f
DataCite Commons2025-06-01 更新70
Next Generation Sequencing Identifies Biased Light Chain Usage and Evidence of Light Chain Gene Replacement in phosphatidylcholine (PtC)-specific CD5+ B cells from dnRAG1 and VH12 mice.
B cells reactive toward phosphatidylcholine (PtC) are enriched in the B1 B cell subset, and express predominantly one of two VH/Vk combinations to confer this specificity: VH12/Vk4/5H and VH11/Vk9. S
NIAID Data Ecosystem60
