Differential miRNA profile in Caco2 Cells in Response to EC-synthetic retinoids

EC-synthetic retinoids are derivatives of vitamin A with diverse biological activities including anti-cancer activity but their potential impact on miRNAs regulation is still unclear. Therefore, the aim of the current study is to explore the effect of two synthetic EC- analogues EC19 and EC23 compared to the parent natural all-trans-retinoic acid ATRA on the differential expression of miRNAs profile using previously reported sensitive Caco-2 cell line as In-vitro model. Highthroughput miRNA sequencing revealed top 10 upregulated and 10 downregulated miRNAs according to their log2 Fold Change in Caco-2 cells compared to WI-38 normal cells.