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Asymmetric Catalytic Synthesis of Thiochromenes via an Acyl Transfer-Initiated Cascade

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https://figshare.com/articles/dataset/Asymmetric_Catalytic_Synthesis_of_Thiochromenes_via_an_Acyl_Transfer-Initiated_Cascade/3472091
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A novel, reagent-free catalytic transformation of α,β-unsaturated thioesters into 2-substituted thiochromenes has been developed, with carbon dioxide as the only byproduct. Amidine-based catalysts, particularly homobenzotetramisole and its analogues, achieve high enantioselectivities and yields in this process.
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2016-07-11
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