Tricomplex of RMC-9945, KRAS G12N, and CypA

Tricomplex of RMC-9945, KRAS G12N, and CypA Descriptor: (2R)-2-{(5S)-7-[(2R,3R)-3-cyclopropyl-1-methylaziridine-2-carbonyl]-2,7-diazaspiro[4.4]nonan-2-yl}-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1R)-1-methoxyethyl]pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-21-(2,2,2-trifluoroethyl)-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-methylbutanamide (non-preferred name), CHLORIDE ION, GLYCEROL, ... Authors: Zhang, D, Bar Ziv, T, Knox, J.E, Yano, J.K. Deposit date: 2024-10-23 Release date: 2025-07-23 Last modified: 2025-08-06 Method: X-RAY DIFFRACTION (1.08 Å) Cite: A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science, 389, 2025