Data Sheet 1_Association between serum potassium levels and haematoma expansion in intracerebral hemorrhage: a retrospective cohort study.pdf

ObjectiveSerum potassium levels are risk factors for intracerebral hemorrhage (ICH), and haematoma expansion (HE) is an important determinant of poor prognosis in patients with ICH. This study investigated the correlation between serum potassium levels and HE after ICH.
Materials and methodsThis retrospective study analyzed serum potassium levels in ICH patients. On the basis of imaging criteria (haematoma volume increase ≥33% or absolute enlargement >6 ml), patients were categorized into the HE subgroup. Differences in serum potassium levels were compared using the Mann–Whitney U-test. Propensity score matching (PSM) was applied to balance baseline characteristics between the HE subgroup and the non-HE subgroup for further comparison. Additionally, adjusted logistic regression analyses and receiver operating characteristic (ROC) curves were employed to evaluate the correlation between HE and serum potassium levels.
ResultsA total of 310 patients with ICH were identified, of whom 50 (16.1%) had HE. After PSM, patients in the HE subgroup presented lower potassium levels than non-HE patients did (3.71 ± 0.52 vs. 3.92 ± 0.52, p = 0.009). Low serum potassium levels were significantly associated with HE (adjusted Odds Ratio (aOR) = 0.36; 95% CI: 0.15–0.80; p = 0.017), with an AUC value of 0.635.
ConclusionLow serum baseline potassium levels are associated with a higher risk of HE after ICH. The relevance of serum potassium levels to severity after ICH is emphasized.