ALS-causing mutations differentially affect PGC-1alpha expression and function in the brain vs. peripheral tissues. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA312104
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资源简介：
Amyotrophic later sclerosis is a motor neuron disease accompanied by metabolic changes. PGC (PPAR gamma coactivator)-1alpha is a master regulator of mitochondrial biogenesis and function and of critical importance for all metabolically active tissues. PGC-1alpha is a genetic modifier of ALS. We used microarray analysis to identify PGC-1alpha target genes in the brain. Overall design: Total mRNA from striata of three homozygous B6.129-Ppargc1atm1Brsp/J and three wild type littermates were used for the analysis.
创建时间：
2016-02-15
