Metadata record for the article: Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

Summary

This
metadata record provides details of the data supporting the claims of the
related article: “Circulating amino acids and amino
acid-related metabolites and risk of breast cancer among predominantly
premenopausal women”.

The
related study investigated associations between breast cancer risk and amino
acid-related metabolites, by profiling circulating metabolites in the blood
plasma of participants of the Nurses’ Health Study II (NHSII).

Type of data:
Demographics and questionnaire data; plasma metabolomics profiles

Subject of
data: 116,429 female registered nurses enrolled in the Nurses’ Health Study II
(NHSII)

Population
characteristics: 1057 cases and 1057 matched controls. Average 53 years old and
predominantly premenopausal (80%) at time of blood collection. At diagnosis,
42% of the women were premenopausal and 46% were postmenopausal. The mean time
between blood collection and diagnosis was 8 years (SD=4.4), ranging from 10
months to 17.4 years. (1st quartile: 4.25 years; 3rd quartile: 11.6 years).

Recruitment:
Registered nurses recruited into the Nurses’ Health Study II (NHSII) study.

Date of data
collection: 1996 to 2011

Geographic
location: United States of America

Data
access

The demographics, questionnaire data and the plasma metabolomics profiles are not publicly available for the following reason: data contain information that could compromise research
participant privacy. Requests to access these data should be made via
http://www.nurseshealthstudy.org/researchers.

Analysis results for all metabolites data are openly available as part of this figshare metadata record in the file titled 'metabolomics_NHS2_breast_cancer_supplementary_data.xlsx'. This file comprises of 4 tabs titled 'supplementary_table1-4'.

Corresponding author(s) for this study

Oana
A. Zeleznik ([e-mail]).

Study approval

The
study protocol was approved by the institutional review boards of the Brigham
and Women’s Hospital and Harvard T.H. Chan School of Public Health, and those
of participating registries as required.