WNT5A-dependent internalization of FZD2, FZD5 and ROR2
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Internalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2010; Hanaki et al, 2012; Yamamoto et al, 2009).
FZD2、FZD5与ROR2的内化过程被认为是以网格蛋白依赖的方式进行的,并且对于激活RAC信号通路至关重要(Kurayoshi等,2007;Sato等,2010;Hanaki等,2012;Yamamoto等,2009)。
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