Reported hypoglycaemic episodes in patients with type-1 diabetes during one year of treatment with metformin or placebo.

Data are included for at total of 99 patients (one patient, in the placebo group, out of a total of 100 randomized patients, had missing data on hypoglycaemia). aNot compared statistically due to equal proportions of patients in treatment groups. bp<0.05 compared to enrolment (Table 2). cLevels of circulating glucose were captured periodically by patients estimating average levels of blood/plasma glucose during hypoglycaemic events. The calibration (plasma or whole blood glucose) of hand held devices was not registrated, nor was devices calibrated at enrolment. Hence, data represent non-standardized plasma and/or blood glucose measurements. Not all patients had available glucose measurements during events. The total number of patients with available measurement was: Minor hypoglycaemia: metformin: n = 47; placebo: n = 49; Major hypoglycaemia: metformin: n = 11; placebo: n = 8. dp = 0.011 and p = 0.209 compared to enrolment for metformin and placebo, respectively (Table 2). ep = 0.049888455.