Reed2004 - Methionine Cycle

Reed2004 - Methionine Cycle

This model is described in the article:

A mathematical model of the
methionine cycle.

Reed MC, Nijhout HF, Sparks R,
Ulrich CM.
J. Theor. Biol. 2004 Jan; 226(1):
33-43
Abstract:

Building on the work of Martinov et al. (2000), a
mathematical model is developed for the methionine cycle. A
large amount of information is available about the enzymes that
catalyse individual reaction steps in the cycle, from
methionine to S-adenosylmethionine to S-adenosylhomocysteine to
homocysteine, and the removal of mass from the cycle by the
conversion of homocysteine to cystathionine. Nevertheless, the
behavior of the cycle is very complicated since many substrates
alter the activities of the enzymes in the reactions that
produce them, and some can also alter the activities of other
enzymes in the cycle. The model consists of four differential
equations, based on known reaction kinetics, that can be solved
to give the time course of the concentrations of the four main
substrates in the cycle under various circumstances. We show
that the behavior of the model in response to genetic
abnormalities and dietary deficiencies is similar to the
changes seen in a wide variety of experimental studies. We
conduct computational "experiments" that give understanding of
the regulatory behavior of the methionine cycle under normal
conditions and the behavior in the presence of genetic
variation and dietary deficiencies.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000698.
To cite BioModels Database, please use:
Chelliah V et al. BioModels: ten-year
anniversary. Nucl. Acids Res. 2015, 43(Database
issue):D542-8.

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