Rattus norvegicus Raw sequence reads

Hyperuricaemic nephropathy (HN) is a common clinical complication of hyperuricaemia and poses a huge threat to human health. Hence, we aimed to prospectively investigate the dysregulated genes, pathways and networks involved in HN by performing whole transcriptome sequencing using RNA sequencing. Six kidney samples from a HN group and a control group were obtained to conduct RNA sequencing. To disclose the relevant signalling pathways, we conducted the analysis of differentially expressed genes, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. A competitive endogenous RNA network was established to reveal the interactions between lncRNAs, circRNAs, mRNAs and miRNAs and investigate the potential mechanisms of HN.