Microarray analysis in acute myeloid leukemia (AML)-derived THP-1 cells expressing or not SAMHD1

Gene expression analysis in THP-1 cells with SAMHD1 knockout (KO) compared to THP-1 control cells expressing endogenous SAMHD1 reveals that the expression of more than 1000 genes is significantly affected by SAMHD1. AML-derived THP-1 cells expressing SAMHD1 (control cells) or with SAMHD1 KO (generated through CRISPR-Cas9 technology) were used to acquire the gene expression profile in the presence or absence of SAMHD1. Three biological replicates for each cell lines were used for the analysis.