Synthesis of Isoquinolines and Heterocycle-Fused Pyridines via Three-Component Cascade Reaction of Aryl Ketones, Hydroxylamine, and Alkynes
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https://figshare.com/articles/dataset/Synthesis_of_Isoquinolines_and_Heterocycle_Fused_Pyridines_via_Three_Component_Cascade_Reaction_of_Aryl_Ketones_Hydroxylamine_and_Alkynes/2507233
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资源简介：
An efficient one-pot synthesis of isoquinolines and heterocycle-fused
pyridines by three-component reaction of aryl ketones, hydroxylamine,
and alkynes is developed. The reaction involves condensation of aryl
ketones and hydroxylamine, rhodium(III)-catalyzed C–H bond
activation of the in situ generated aryl ketone oximes, and cyclization
with internal alkynes. This protocol enables rapid assembly of multisubstituted
isoquinolines as well as γ-carbolines, furo[2,3-c]pyridines, thieno[2,3-c]pyridines, and benzofuro[2,3-c]pyridines from readily available substrates.
创建时间：
2016-02-20
