Characteristics of Extracellular Vesicle-Derived lncRNAs during the Progression of HBV-Related Hepatocellular Carcinoma

Using High-Throughput Sequencing to Conduct Integrated Analysis of the Whole Transcriptome in Blood sEVs from HBV-Associated Liver Disease Cohort Overall design: Patients with HBV-associated liver diseases—chronic hepatitis B (CHB), liver cirrhosis (LC), benign liver disease (HA), and hepatocellular carcinoma (HCC)—were selected as the study cohort. High-throughput sequencing was utilized to perform comprehensive whole transcriptome analysis (mRNA, miRNA, lncRNA, and circRNA) of small extracellular vesicles (sEVs) isolated from serum .