Results of the validation experiments.

The table presents the validation experiments for each of the four networks (i..e, OpenBioLink, permuted OpenBioLink, In-House, and permuted In-House) using two variants of the algorithm (i.e., all paths and simple paths) based on two different prioritization criteria (see Methods) as well as the results yielded when only considering the shortest path between a drug-disease pair. For each experiment, we report the relative number of true positives in the list of drug-disease pairs prioritized by drug2ways. The proportion of true positives recovered by both variants of drug2ways in the two original networks are significantly higher than chance level (i.e., 3.19% for OpenBioLink and 3.76% for the In-House network).