Drug Mechanism Database

Drug Mechanism Database (DrugMechDB) compiles curated mechanism of action linking a drug to a disease. Most drug mechanisms are described simply as a protein target, or a pathway, that then treats the disease. However, there are usually more steps across a biological knowledge graph required to traverse from the target through its mechanism to the reduction of a disease. DrugMechDB catalog a subset of known drug-disease indications as a path through a network of biomedical entities.药物机制数据库（Drug Mechanism Database，缩写DrugMechDB）汇集了经专业人员审核整理的、将药物与疾病关联的作用机制。大多数药物作用机制仅被简单描述为某一蛋白靶点或信号通路，进而实现疾病治疗。然而，从靶点通过其作用机制追溯至疾病缓解的过程中，生物知识图谱（biological knowledge graph）通常包含更多的关联步骤。DrugMechDB将已知的部分药物-疾病适应症以生物医学实体网络中的路径形式进行编目收录。

搜集汇总

背景与挑战

背景概述

DrugMechDB是一个收集经过整理药物作用机制的数据集，通过生物医学实体网络路径将药物与疾病关联起来。它系统地记录了药物如何通过蛋白质靶点或通路等步骤治疗特定疾病，提供了丰富的药物-疾病对应关系示例。