Transcriptomic analysis of skin from mice subjected to chronic low-dose radiation, hindlimb unloading or a combination of both
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https://osdr.nasa.gov/bio/repo/data/studies/OSD-237
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资源简介：
The purpose of this study was to evaluate transcriptional changes in mouse skin using a ground-based model for spaceflight. This model includes prolonged unloading and low-dose irradiation. Low-dose-rate gamma-radiation was delivered to 6-month old female C57BL/6J mice using 57Co plates (0.04 Gy) to simulate the radiation environment of spaceflight. Anti-orthostatic tail suspension was used to model the unloading, fluid shift, and physiological stress aspects of the microgravity component of spaceflight. Mice were hindlimb suspended and/or irradiated for 21 days. Mice were euthanized and dorsal skin was collected 7 days following treatment. RNA sequencing data was generated to assess transcriptional changes in these skin samples.
提供机构：
NASA GeneLab
创建时间：
2020-08-19
