Neuropsychological profile of CBS patients according to PiB status.

aPiB-positive v PiB-negative, P<0.05.
bPiB-negative v Controls, P<0.05.
cPiB-positive v Controls, P<0.05.
Although both CBS groups demonstrated cognitive impairment compared to controls, PiB-positive CBS patients demonstrated more cognitive impairment than PiB-negative cases, with significant visuospatial impairment, and executive dysfunction. In addition, there was a trend for impaired memory in the PiB-positive group. Note: some tasks that required manipulation of a pencil, such as the Rey-Osterrieth Complex Figure and Trails, had to be abandoned in some CBS patients due to severe apraxia of the dominant limb.