Mrc1 and DNA polymerase _ function together in linking DNA replication and the S phase checkpoint

Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint酵母Mrc1作为后生动物Claspin的直系同源物，既是正常DNA复制叉的核心组分，亦是S期检查点的介导因子。