HTS resultsa.

a201,200 compounds were screened in two stages, initially identifying 175 compounds that inhibited growth of sdh2Δ mutant yeast cells at 10 µM, followed by high-resolution growth curve analysis comparing effects of each compound at 50 µM (and then various lower concentrations) on sdh2Δ mutant yeast vs. WT yeast. 14 compounds showed differential growth inhibition, with 12 selectively inhibitory to the sdh2Δ mutant yeast. These 12 compounds were not differentially toxic to the nhp6AΔ gene disruption strain carrying the same NatR selectable marker as the sdh2Δ strain.