The_transcriptomic_effect_of_brain_specific_allelic_imbalance_of_Trappc9

Homozygous mutations in human TRAPPC9 have been found in ~20 individuals with a rare disorder characterised by developmental delay, intellectual disability and childhood onset obesity. We generated a Trappc9 knockout mouse and demonstrated the gene has an allelic imbalance in expression determined by parent of origin. Here we carried out RNA sequencing in the hippocampus and hypothalamus of mice of four genotypes with different Trappc9 doses, to ascertain the gene with expression altered by Trappc9 dose dependence.