Immunohistochemical analysis of TNF-? in endomyocardial tissues obtained from drug-related victims ( and ) and SND ()

Overview of transverse sections with cytoplasmic localization of newly synthesized myocytic TNF-α of pattern type I () and II (). The longitudinal section () showing intracellular production of TNF-α of pattern type III in cardiomyocytes. TNF- α protein was also present in cardiac MCs (arrows). Analysis of TNF-α in longitudinal section of endomyocardial tissues obtained from a healthy control that died in unnatural causes (). Original magnification × 200.<b>Copyright information:</b>Taken from "Pathogenic role of cardiac mast cell activation/degranulation, TNF-α, and cell death in acute drug-related fatalities"Vascular Health and Risk Management 2007;3(6):1053-1062.Published online Jan 2007PMCID:PMC2350147.© 2007 Perskvist et al, publisher and licensee Dove Medical Press Ltd.