Scrib

ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN astrocyte cell migration; neurotransmitter receptor transport, endosome to postsynaptic membrane; regulation of postsynaptic neurotransmitter receptor internalization; PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); holoprosencephaly (ortholog); FOUND IN cell-cell junction; extrinsic component of postsynaptic density membrane; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil

编码一种具有信号适配器活性的蛋白质（同源蛋白）；参与星形胶质细胞迁移；神经递质受体运输，从内体至突触后膜；调控突触后神经递质受体内化；参与Wnt信号通路、平面细胞极性通路；与Brown-Vialetto-Van Laere综合征2（同源蛋白）、单纯性大疱性表皮松解症伴肌肉萎缩症（同源蛋白）、无脑儿（同源蛋白）相关；存在于细胞间连接处；突触后密度膜的外在组分；谷氨酸能突触；与2,3,7,8-四氯二苯并-对二恶英、4,4'-磺酰二苯酚、6-丙基-2-硫基尿嘧啶相互作用。