Supplementary Material for: Histiocytosis Presenting as Bilateral Adrenal Masses: A Case Report

Adrenal masses are a rare diagnosis in children, with bilateral masses even less common. At present, appearance of the mass on imaging and histology can give important clues to the diagnosis, however there is significant overlap in 10-30% of cases and it can be difficult to distinguish benign from malignant adrenal masses. As a result, the clinical presentation remains a large part of the diagnostic process, as well as thorough Endocrinology evaluation to determine if the tumor is functional versus non-functioning. We present a recent case of bilateral adrenal masses in a pediatric patient at our institution, with an unusual diagnosis of Histiocytosis. In this case the diagnosis was unclear, until genetic testing and pathology allowed for expedient diagnosis and targeted therapy for this patient.