Whole Genome Sequencing: Identification of genomic differences correlated to Cryptococcus neoformans pathogenicity. Cryptococcus neoformans

We sequenced the whole genomes of 28 Cryptococcus neoformans isolates of the most frequently observed sequence type (ST) ST5 in China, 14 from the HIV-uninfected patients and 14 from the HIV-infected patients, and performed a comparative study to identify potential correlations between genetic variation and virulence, by comparing the de novo genome assemblies of 28 isolates against the finished reference strain H99.