Crystal structure of PLK4 and RP1664 complex
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Crystal structure of PLK4 and RP1664 complex Descriptor: 5-cyclopropyl-N~2~-[2,6-difluoro-4-(methanesulfonyl)phenyl]-N~2~-methyl-6-(1-methyl-1H-imidazol-4-yl)-N~4~-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, SULFATE ION, Serine/threonine-protein kinase PLK4 Authors: Pau, V.P.T, Mao, D.Y.L, Mader, P, Maderova, Z, Zimmermann, M, Sicheri, F. Deposit date: 2025-04-11 Release date: 2025-05-28 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor. J.Med.Chem., 68, 2025
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2025-04-11
