BDNF-TrkB signalling depletion from the indirect pathway spiny projection neurons (iSPN) leads to age-dependent spontaneous hyperlocomotion.

Therefore, we have established a unique mouse model that provides a rare example of an age-dependent locomotor defect to identify the genes and associated molecular pathways relevant to maintaining locomotor control. Thus, we performed gene expression profiling analysis using data from RNA-seq of 2 different striatal populations at two time points in the presence and absence of the TrkB signalling. Comparative gene expression profiling analysis of RNA-seq data from a limited number of purified adult or aged murine brain neurons lacking BDNF-TrkB signalling versus control mice.