BDNF-TrkB signalling depletion from the indirect pathway spiny projection neurons (iSPN) leads to age-dependent spontaneous hyperlocomotion.

Therefore, we have established a unique mouse model that provides a rare example of an age-dependent locomotor defect to identify the genes and associated molecular pathways relevant to maintaining locomotor control. Thus, we performed gene expression profiling analysis using data from RNA-seq of 2 different striatal populations at two time points in the presence and absence of the TrkB signalling. Comparative gene expression profiling analysis of RNA-seq data from a limited number of purified adult or aged murine brain neurons lacking BDNF-TrkB signalling versus control mice.为此，我们构建了一种独特的小鼠模型，该模型可为识别维持运动控制相关的基因及关联分子通路提供罕见的年龄依赖性运动缺陷研究范例。据此，我们针对存在与缺失TrkB信号通路（TrkB signalling）的两种不同纹状体细胞群，在两个时间点采集了RNA测序（RNA-seq）数据并开展基因表达谱分析。本研究针对少量纯化的成年或老年BDNF-TrkB信号通路缺陷小鼠脑神经元的RNA测序数据，与对照组小鼠的同类数据进行了对比基因表达谱分析。