The combined effect of prognostic factors and treatment on breast cancer stage I-IIb.

Model 1: Crude.Model 2: Adjusted for year of diagnosis (1992–93, 1994–95, 1996–97, 1998–99, 2001–01, 2002–03, 2004–05).Model 3: Adjusted for year of diagnosis, tumour stage (tumour size, lymph node status).Model 4: Adjusted for year of diagnosis, all tumour characteristics (tumour size, lymph node status, tumour grade, hormone receptor status, multifocality).Model 5: Adjusted for year of diagnosis, all tumour characteristics and treatment (preoperative treatment, type of surgery, radiotherapy, chemotherapy and endocrine therapy).Estimated RER with 95% CI for women aged 20–69 years, diagnosed with primary breast cancer stage I-IIb between 1992 and 2005 (18 631 women), by age at diagnosis, adjusted for year of diagnosis, tumour stage, tumour characteristics and treatment.