Inhaled titanium dioxyde-induced gene expression profile in rat lung

In this work we study the pulmonary toxicological properties of titanium dioxyde nanoparticles using molecular toxicological approach. For this, we exposed F344 rats by nose-only inhalation 6 hours/day, 5 days/week for 4 weeks. Lung samples have been collected up to 28 days after the end of exposure and transcriptomics analysis were performed. 19 months old male F344 rats were exposed by nose-only inhalation 6 hours/day, 5 days/week for 4 weeks to titanium dioxyde nanoparticles (TiO2). Titanium dioxyde nanoparticles-induced gene expression profile in rat lung was performed 0 and 28 days post exposure (2 time points). Each time point is composed of 6 control, 6 exposed rats. A total of 23 samples (microarrays) was used.